Titles of thesis work

Undergraduate Project Topics for Thesis Work (last updated: 27/09/2017)


1. Interrogation of spinal dorsal horn circuits with electrophysiological and optogenetic tools

Supervisors: Dr. Péter Szücs, Dr. Miklós Sivadó


2. Local synaptic connections of projection neurons in spinal lamina I

Supervisors: Dr. Péter Szücs, Dr. Miklós Sivadó


3. Light- and electron microscopy level analysis of the axons and axon collaterals of spinal lamina I projection neurons

Supervisors: Dr. Péter Szücs, Éva Kókai


4. Morphometric analysis of excitatory and inhibitory interneurons in the spinal dorsal horn

Supervisors: Dr. Péter Szücs, Éva Kókai


5. Possible applications of morphofunctional matrices for classification of neurons (computer modelling)

Supervisor: Dr. Ervin Wolf


We are testing our new MFM (morphofunctional matrix) method to establish the usefulness of this technique in classification of neurons based on both neuronal geometry and on the way how dendrites of different neurons conduct postsynaptic potentials. We use computers to simulate and analyse impulse propagation in geometrically faithful models of neurons and then apply statistical procedures to group these neurons based on their dendritic structure and their impulse propagation. Finally, we check whether or not neurons within a given MFM group are related to one another based on other independent studies so that we can justify the MFM method.



6. Three-dimensional reconstruction of thalamocortical axons in the primary somatosensory cortex of rats

Supervisor: Dr. Zoltan Kisvarday


7. Mapping of synapses on dendrites of GABAergic neuron subtypes in the cerebral cortex

Supervisor: Dr. Petra Talapka


The remarkable diversity of excitatory and inhibitory neurons in their morphology, electrophysiology and their synaptic properties contributes to the functional complexity of neocortical microcircuits. The major goal of the project to explore the complete synaptic coverage along the soma-dendritic surface of subtypes of inhibitory GABAergic neurons (e.g. calretinin, parvalbumin, calbindin, NO-synthase, neuropeptide Y, somatostatin, cholecystokinin, vasoactive intestinal polypeptide and choline-acetyltransferase) by immunohistochemistry and quantitative electron microscopy.


8. Investigation of contour integration processing in the primary visual cortex using voltage sensitive dye imaging

Supervisor: Dr. Zoltan Kisvarday


9. Role of PACAP signalling in cartilage differentiation and regeneration

Supervisor: Dr. Tamás Juhász


10. The role of the molecular clock in healthy and osteoarthritic chondrocytes

Supervisor: Dr. Csaba Matta


11. Investigation of signalling mechanisms that regulate cartilage development and maturation

Supervisor: Dr. Róza Zákány


12. Role of pro-inflammatory cytokines in neuron-glia interaction during inflammatory pain states

Supervisor: Dr. Krisztina Holló


13. Investigation of neuronal network development in the spinal cord

Supervisor: Dr. Zoltán Mészár


14. Quantitative morphological studies of primary afferent-motoneuron
connections in the frog's brainstem.

Supervisor: Dr. András Birinyi


15. The role of astrocytes in spinal pain processing

Supervisor: Dr. Zoltán Hegyi


16. The endocannabinoid-mediated modulation of spinal nociception

Supervisor: Dr. Zoltán Hegyi


17. The role of the extracellular matrix in the regeneration of the nervous system

Supervisor: Dr. Klára Matesz

Extracellular matrix (ECM) of the central nervous system plays important role in the plasticity of neuronal contacts. Thus ECM’s role in regeneration is also suspected.

18. Regeneration of the vestibular system in the rat

Supervisors: Dr. Botond Gaál and Dr. Éva Rácz

The vestibular system is among the most plastic systems in the brain. It serves as great model for regeneration research.

19. Regeneration of the optic nerve in the frog

Supervisor: Dr. Botond Gaál

Unlike in mammals, amphibian’s central nervous system has high regenerative capacity.  An injured optic nerve of frog gains back its functions within few weeks.


20. Extracellular matrix molecules in the motor nuclei of the eye in the mouse

Supervisor: Dr. Botond Gaál

In the eye movement nuclei of mice the extracellular matrix composition shows specific patterning. Presumably it is associated to the different functional groups of acetyl-choline motoneurons.

21. Distribution of the extracellular matrix in the red nucleus and pararubral area

Supervisor: Dr. Éva Rácz

In the red nucleus the assembly of extracellular matrix is associated to the function, morphology and neurochemical properties of neurons.

22. Expression of extarcellular matrix molecules in the olfactory system of the rat

Supervisors: Dr. Klára Matesz and Andrea Hunyadi

The superb plastic neuronal network of the olfactory bulb exhibits a specific extracellular matrix assembly.

23. Extracellular matrix in the developing brain stem

Supervisor: Dr. Ildikó Wéber

The various extracellular matrix molecules of the brain express in proper periods of the embryonic development. This sequence is followed in mouse embryos.